WHITE BLOOD CELLS AND PLATELETS  (PART -2)









                                                  QUESTIONS


1. A newborn baby presented with profuse bleeding from the umbilical stump after birth. Rest of the examination and PT, APTT are within normal limits. Most likely diagnosis is which of the following?
(a) Factor X deficiency 
(b) Glanzmann’s thrombasthenia 
(c) von Willebrand disease
(d) Bernard Soulier disease 
 
2. A 25 years old asymptomatic female underwent a preop coagulation test. Her bleeding time is 3minutes, PT is 15/14sec, a PTT is 45/35 sec, platelet count is 2.5 lac/ mm3 and factor VIII levels were 60IU/dL. What is her most likely diagnosis? 
(a) Factor IX deficiency 
(b) Lupus anticoagulant 
(c) Factor VIII inhibitors 
(d) VWD – Type III 
 
3. True about prothrombin time to ?
(a) Immediate refrigeration to preserve factor viability
(b) Platelet-rich plasma is essential 
(c) Done within 2 hours 
(d) Activated with kaolin 

 4. A 22 year old female having a family history of autoimmune disease presents with the complaints of recurrent joint pains. She has now developed petechial hemorrhages. She is most likely to have which of the following disorders? 
 (a) Megakaryocytic thrombocytopenia 
(b) Amegakaryocytic thrombocytopenia 
(c) Platelet function defects/Functional platelet defect 
(d) Acquired Factor VIII inhibitors
 
5. Patient with bleeding due to platelet function defects has which of the following features? 
 (a) Normal platelet count and normal bleeding time
 (b) Normal platelet count and increased bleeding time
 (c) Decreased platelet count and increased bleeding time 
(d) Normal platelet count and decreased bleeding time
 
6. A 9-year-old boy presents with elevation in both PT and aPTT. What is the diagnosis ?
(a) Defect in extrinsic pathway 
(b) Defect in intrinsic pathway 
(c) Platelet function defect 
(d) Defect in common pathway 
 
7. All are true about thrombotic thrombocytopenic purpura except? 
 (a) Microangiopathic hemolytic anemia 
(b) Thrombocytopenia 
(c) Normal complement level 
(d) Grossly abnormal coagulation tests 

 8. D.I.C. is seen in ?
 (a) Acute promyelocytic leukemia 
(b) Acute myelomonocytic leukemia 
(c) CMC 
(d) Autoimmune hemolytic anemia 

 9. All of the following can cause megakaryocytic thrombocytopenia, except ?
(a) Idiopathic thrombocytopenia purpura 
(b) Systemic lupus erythematosus 
(c) Aplastic anemia 
(d) Disseminated intravascular coagulation (DIC)

 10. A patient with cirrhosis of liver has the following coagulation parameters, Platelet count 2,00,000, Prothrombin time 25s/12s, Activated partial thromboplastin time 60s/35s, thrombin time 15s/15s. In this patient ?
(a) D-dimer will be normal 
(b) Fibrinogen will be < 100 mg
 (c) ATIII will be high 
(d) Protein C will be elevated 
 
11. The presence of small sized platelets on the peripheral smear is characteristic of ?
(a) Idiopathic thrombocytopenia purpura (ITP)
 (b) Bernard Soulier syndrome 
(c) Disseminated intravascular coagulation 
(d) Wiskott Aldrich syndrome 
 
12. Platelet aggregation in vivo is mediated by ?
 (a) Serotonin
(b) Ig mediators.
 (c) Interaction among the leukocytes
 (d) Interaction among the platelets 
(e) Macromolecules.
 
13. Conditions associated with incoagulable state ?
 (a) Abruption placentae 
 (b) Acute promyelocytic leukemia 
(c) Severe falciparum malaria 
(d) Snake envenomation 
(e) Heparin overdose 
 
14. In DIC, which is/are seen ?
 (a) Normal aPTT 
(b) Increased PT 
(c) Increased factor VIII
 (d) Decreased fibrinogen 
(e) Decreased platelets

15. Causes for DIC are ?
 (a) Anaerobic sepsis 
(b) Malignancy 
(c) Lymphoma 
(d) Leukemia 
(e) Massive blood transfusion

               
                                                    ANSWERS


1) b   2) c   3) c   4) d   5) b   6) d   7) d   8) a   9) c   10) a   11) d   12) a b d e   13) a b d e    14) b   
15) a b d