WHITE BLOOD CELLS AND PLATELETS  (PART -1)






                                                QUESTSIONS


 1. Flow cytometry is done in ?

(a) Polycythemia 

(b) Thrombocytosis 

(c) Neutrophilia 

(d) Lymphocytosis 

 2. Myelofibrosis leading to a dry tap on bone marrow aspiration is seen with which of the following conditions? 

 (a) Burkitt’s lymphoma

 (b) Acute erythroblastic leukemia 

(c) Acute megakaryocytic leukemia 

(d) Acute undifferentiated leukemia 

 3. Marker of myeloid cancers ?

(a) S100 

(b) HMB45 

(c) Common leukocyte antigen 

(d) Cyto-keratin 

 4. Adult patient presents with generalized lymphadenopathy and blood film shows 70% immature looking lymphocytes. What should be the next best investigation? 

(a) Genotyping/karyotyping 

 (b) Immunophenotyping 

(c) Bone marrow

 (d) Peripheral smear study 

 5. Which of the following statements in context of leukemias is true? 

(a) Chronic myeloid leukemia occurs beyond 50 years of age 

(b) Hairy cell leukemic in less than 50 years has a good prognosis 

(c) Acute lymphoid leukemic in less than 1 year has a poor prognosis

(d) Chronic lymphocytic leukemia occurs in less than 50 years of age 

 6. In an ablated animal, myeloid series cells are injected. Which of following is seen after incubation period?

 (a) Fibroblast 

 (b) T lymphocytes 

(c) RBC 

(d) Hematopoetic stem cell 

 7. A young boy came with dyspnea and was found to have a mediastinal mass. Which of the following is known to produce mediastinal lymphadenopathy? 

(a) Diffuse large B cell Lymphoma

 (b) B cell rich T cell lymphoma 

(c) Mediastinal rich B cell lymphoma 

(d) T cell Lymphoblastic ALL 

 8. Which of the following is the least likely to be a preleukaemic condition? 

 (a) Paroxysmal nocturnal haemoglobinuria 

(b) Aplastic anaemia 

(c) Paroxysmal cold haemoglobinuria 

(d) Myelodysplastic syndrome

 9. A 6 year old child presents with pallor that required two blood transfusions previously. He has now developed fever and petechial haemorrhages. His hemoglobin is is 9 g/dL, platelet count is 20,000/mm3 and TLC is 60,000/ mm3 . Flow cytometry reveals the cells to be CD10+ve, MPO+ ve, CD 19 + ve, CD 33 – ve, CD 117 + ve, and CD3 – ve. Which of the following is the most likely diagnosis? 

(a) ALL 

(b) AML

 (c) Mixed phenotypic leukaemia 

(d) Undifferentiated leukaemia

 10. Poor prognostic factor for ALL is ?

 (a) Hyperdiploidy 

(b) t(9;22) t(4;11) 

(c) Age at presentation is 2-8 yrs 

(d) Total Leucocyte count <50000 

 11. All the following are poor prognostic indicators in AML except ?

(a) Inv 16 

(b) Complex karyotype 

(c) AML M7 

(d) Deletion 7q 

 12. Most specific marker for myeloid series is ?

(a) CD 34 

 (b) CD 45

 (c) CD 99 

(d) CD 117

 13. t (2,8) is associated with ?

 (a) T cell ALL 

(b) B cell ALL 

(c) CML

 (d) CLL 

 14. ALL L3 morphology is a malignancy arising from which cell lineage? 

 (a) Mature B-cell

 (b) Precursor B-cell 

(c) Immature T-cell 

(d) Mixed B cell and T-cell

15. Non-specific esterase is positive in all the categories of AML except ?

(a) M3

 (b) M4 

(c) M5 

(d) M6

 

                                                  ANSWERS


1) d   2) c   3) c   4) b   5) c   6) c   7) d   8) c   9) c   10) b   11) a   12) d   13) b   14) a   15) d