ANEMIA AND RED BLOOD CELLS  (PART -3)





                                                    QUESTIONS


1. In DIC, following are seen except ?

(a) Fibrinogen decreased 

(b) Thrombocytopenia 

(c) Normal APTT 

(d) PT elevation

2. D.I.C is seen in ?

(a) Acute promyelocytic leukemia 

(b) Acute myelomonocytic leukemia 

(c) CML 

(d) Autoimmune haemolytic anemia 

3. Intravascular hemolysis occurs in?

 (a) Hereditary spherocytosis

 (b) Autoimmune haemolytic anemia 

(c) Paroxysmal nocturnal hemoglobinuria

 (d) Thalassemia 

4. Bite cells are seen in?

 (a) G6PD deficiency 

(b) Sickle cell anemia 

(c) Hereditary spherocytosis 

(d) Trauma 

5. Cold agglutinin is?

 (a) IgG 

(b) IgM

 (c) IgA

 (d) IgD 

6. Helmet cells are characteristic of anemia of ?

 (a) Hemolytic uremic syndrome 

(b) Polysplenia

 (c) Spherocytosis 

(d) Acanthocytosis

 7. Schistocyte is/are found in?

 (a) TTP 

(b) March hemoglobinuria 

(c) Severe iron deficiency 

(d) All of the above 

8. PNH due to defect in ?

(a) CD 59 

(b) CD 15 

(c) CD 100

 (d) CD 20

 9. All are the features of hemolytic anemia except?

 (a) Hemoglobinuria 

(b) Jaundice

 (c) Increased haptoglobin 

(d) Hemosiderinuria

10.G6PD help in maintaining the integrity of RBC by? 

(a) Controlling reduction stress on RBC 

(b) Controlling oxidative stress on RBC 

(c) Maintaining flexibility of cell membrane

 (d) Component of electron transport chain

11. The primary defect which lead to stickle cell anemia is ?

 (a) An abnormality in porphyrin part of haemoglobin 

(b) Substitution of valine by glutamate in the β-chain of HbA 

(c) Replacement of glutamate by valine in β-chain of HbA 

(d) A nonsense mutation in the β-chain of HbA

12. In α-thalassemia, which of the following is a finding? 

(a) No β-chain 

(b) Excess α-chain

(c) No α-chain 

(d) Relative excess of β, γ, and δ chains

 13. In sickle cell anemia defect is in which chain?

 (a) Alpha chain 

(b) Beta chain 

(c) Both the chains 

(d) None of these 

14. Sickle cell red blood cells have?

 (a) Altered stability

 (b) Altered functions

 (c) Decreased oxygen carrying capacity 

(d) Protective action against adult malaria

 15. Bone infarcts are seen in ?

(a) Iron deficiency anemia 

(b) Thalassemia 

(c) Sickle cell anemia 

(d) Hereditary spherocytosis

                                          

                                             ANSWERS

1) c   2) a   3) c   4)' a   5) b   6) a   7) d   8) a   9) c   10) b   11) c   12) d   13) b   14) d   15) c