CELL (INJURY PART 3)    

                                                                

                                                                 QUESTIONS

1. CD 95 is a marker of ?

(a) Intrinsic pathway of apoptosis 

(b) Extrinsic pathway of apoptosis 

(c) Necrosis of cell 

(d) Cellular adaption

2. Which of the following is the characteristic of irreversible injury on electron microscopy?

 (a) Disruption of ribosomes  

(b) Amorphous densities in mitochondria 

(c) Swelling of endoplasmic reticulum 

(d) Cell swelling

3. Caspases are associated with which of the following? 

(a) Hydopic degeneration 

 (b) Collagen hyalinization 

(c) Embryogenesis 

(d) Fatty degeneration

4. Caspases are seen in which of the following? 

(a) Cell division 

(b) Apoptosis 

(c) Necrosis 

(d) Inflammation

5. Light microscopic characteristic feature of apoptosis is? 

(a) Intact cell membrane 

 (b) Eosinophilic cytoplasm 

(c) Nuclear moulding 

(d) Condensation of the nucleus

6. Coagulative necrosis is found in which infection? 

(a) TB 

 (b) Sarcoidosis

 (c) Gangrene

 (d) Fungal infection

7. Organelle which plays a pivotal role in apoptosis is?

 (a) Cytoplasm 

(b) Golgi complex 

(c) Mitochondria 

(d) Nucleus

8. All of the following statements are true regarding reversible cell injury, except ?

 (a) Formation of amorphous densities in the mitochondrial matrix 

(b) Diminished generation of adenosine triphosphate (ATP)

(c) Formation of blebs in the plasma membrane

 (d) Detachment of ribosomes from the granular endoplasmic reticulum

9. Fibrinoid necrosis may be observed in all of the following, except?

(a) Malignant hypertension 

(b) Polyarteritis nodosa 

(c) Diabetic glomerulosclerosis 

(d) Aschoff’s nodule

10. In apoptosis, Apaf-I is activated by release of which of the following substances from the mitochondria?

 (a) Bcl-2  

(b) Bax 

(c) Bcl-XL 

(d) Cytochrome C

11. Which of the following is an anti-apoptotic gene? 

(a) C-myc 

(b) p 53 

(c) bcl-2 

(d) bax

12. Annexin V on non-permeable cell is indicative of ?

(a) Apoptosis 

(b) Necrosis 

(c) Cell entering replication phase 

(d) Cell cycle arres

13. Ultra-structural finding of irreversible injury ?

(a) Ribosomal detachment from endoplasmic reticulum 

(b) Amorphous densities in mitochondria 

(c) Formation of phagolysosomes 

 (d) Cell swellingt

14. Caspases are involved in ?

 (a) Necrosis 

(b) Apoptosis 

(c) Atherosclerosis 

(d) Inflammation

15. True about Apoptosis are all except?

 (a) Inflammation is present 

(b) Chromosomal breakage

 (c) Clumping of chromatin 

(d) Cell shrinkage

16. A patient Fahim presents to the hospital with jaundice, right upper quadrant pain and fatigue. He tests positive for hepatitis B surface antigen. The serum bilirubin levels is 4.8mg/dl (direct is 0.8mg/dl and indirect bilirubin is 4.0mg/dl), AST levels is 300 U/L, ALT is 325 U/L and alkaline phosphatase is within normal limits. The elevation in AST and ALT can be explained by which of the following? 

(a) Bleb formation 

(b) Cell membrane rupture 

(c) Clumping of nuclear chromatin 

(d) Swelling of endoplasmic reticulum

17. A 23-year-old lady Sweety was driving her car when she had to apply brakes suddenly. She suffered from “steering wheel” injury in the right breast. After 5 days of pain and tenderness at the site of trauma, she noticed the presence “lump” which was persistent since the day of trauma. Dr. M. Spartan does an excision biopsy and observed the presence of an amorphous basophilic material within the mass. The amorphous material is an example of  ?

(a) Apocrine metaplasia 

(b) Dystrophic fat necrosis 

(c) Enzymatic fat necrosis 

(d) Granulomatous inflammation

18. Fournier’s gangrene is seen in ?

 (a) Nose 

(b) Scrotal skin 

(c) Oral cavity 

(d) All are true

18. Coagulative necrosis is seen in ? 

(a) Brain 

(b) Breast 

(c) Liver 

(d) All

19. About apoptosis, true statement is ? 

 (a) Injury due to hypoxia 

(b) Inflammatory reaction is present 

(c) Councilman bodies is associated with apoptosis 

(d) Cell membrane is damaged

20. Apoptosis is alternatively called as ?

(a) Ischemic cell death 

(b) Programmed cell death 

(c) Post traumtic cell death 

(d) All


                                                      ANSWERS


1) b   2) b   3) c   4) b   5) d   6) a   7)c   8) a   9) c   10) d   11) c   12) a   13) b  14) b   

15) a   16) b   17) b   18) b   19) c   20) b