INFLAMMATION (PART -1)

 



                                                         QUESTIONS

  1. In acute inflammation endothelial retraction leads to ?

 (a) Delayed transient increase in permeability 

(b) Immediate transient increase in permeability 

(c) Delayed prolonged increase in permeability 

(d) Immediate transient decrease in permeability

2. After binding of complement and antibody on the surface of encapsulated bacteria, the process of phagocytosis by polymorphonuclear leukocytes involves which of the following? 

 (a) Fc and C3b 

(b) Receptor-mediated endocytosis 

(c) Respiratory burst 

(d) Pseudopod extension 

3. Free radicals are generated by all except ?

(a) Superoxide dismutase 

(b) NADPH Oxidase 

(c) Myeloperoxidase 

(d) NO synthase

4. Which among the following is the hallmark of acute inflammation? 

(a) Vasoconstriction 

(b) Stasis

 (c) Vasodilation and increase in permeability 

(d) Leukocyte margination

5. Main feature of chemotaxis is ?

 (a) Increased random movement of neutrophils

 (b) Increase adhesiveness to intima 

(c) Increased phagocytosis 

(d) Unidirectional locomotion of the neutrophils

6. Characteristic of acute inflammation is ? 

 (a) Vasodilation and increased vascular permeability

 (b) Vasoconstriction 

(c) Platelet aggregation 

(d) Infiltration by neutrophils

7. Which of the following helps in generating reactive O2 intermediates in the neutrophils? 

(a) NADPH oxidase 

(b) SOD (superoxide dismutase) 

(c) Catalase 

(d) Glutathione peroxidas

8. Basement membrane degeneration is mediated by: 

(a) Metalloproteinases 

(b) Oxidases 

(c) Elastases 

(d) Hydroxylases

9. Delayed prolonged bleeding is caused by ?

 (a) Histamine 

 (b) Endothelial retraction 

(c) IL-1

 (d) Direct injury to endothelial cells

10. Earliest transient change following tissue injury will be ?

 (a) Neutropenia 

(b) Neutrophilia

 (c) Monocytosis

 (d) Lymphocytosis

11. All of the following vascular changes are observed in acute inflammation, except ?

(a) Vasodilation 

(b) Stasis of blood 

(c) Increased vascular permeability 

(d) Decreased hydrostatic pressure

12. The following host tissue responses can be seen in acute infection, except ?

 (a) Exudation

 (b) Vasodilation

 (c) Margination

 (d) Granuloma formation

13. Oxygen dependent killing is done through 

(a) NADPH oxidase 

 (b) Superoxide dismutase 

(c) Catalase

 (d) Glutathione peroxidase

14. Which of the following is not true? 

(a) NADPH oxidase generate superoxide ion 

(b) MPO kills by OCl–

(c) Chediak-Higashi syndrome is due to defective phagolysosome formation

 (d) In Bruton’s disease there is normal opsonization

15. Nitroblue tetrazolium test is used for?

 (a) Phagocytes

 (b) Complement

 (c) T cell

 (d) B cell

16. In acute inflammation due to the contraction of endothelial cell cytoskeleton, which of the following results? 

 (a) Delayed transient increase in permeability

 (b) Early transient increase 

(c) Delayed permanent increase 

(d) Early permanent increase

                                                               

                                                  ANSWERS

1) c   2) d   3) a   4) c   5) d    6) a   7) a   8) a   9) d   10) b   11) d   12) d   13) a   14) d   15) a   16) b