NEOPLASIA (PART -2)





                                                 QUESTIONS

 

1. Which of the following is most reliable feature of malignant transformation of pheochromocytoma?

 (a) Presence of mitotic figures 

(b) Presence of metastasis to other organs 

(c) Vascular/ capsular invasion 

(d) All of the above 

2. Overgrowth of a skin structure at a localised region is ?

(a) Hamartoma 

(b) Malignant tumor 

(c) Choristoma 

(d) Polyp 

3. Cell-matrix adhesions are mediated by? 

(a) Cadherins 

(b) Integrins

(c) Selectins 

(d) Calmodulin 

4. Which of the following is not a labile cell?

 (a) Bone marrow 

(b) Epidermal cells 

(c) Small intestine mucosa 

(d) Hepatocytes 

5. Which one is not the pre cancerous condition? 

(a) Crohn’s disease

 (b) Ulcerative colitis 

(c) Leukoplakia 

(d) Xeroderma pigmentosum 

6. Which of the following features differentiates invasive carcinoma from carcinoma in situ? 

(a) Anaplasia

 (b) Number of mitosis 

(c) Basement membrane invasion 

(d) Pleomorphism

 7. Sure sign of malignancy is ?

 (a) Mitoses

 (b) Polychromasia 

(c) Nuclear pleomorphism 

(d) Metastasis

 8. Bimodality of incidence occurs in all, except ?

 (a) Cancer penis in male 

(b) Hodgkin’s diseases 

(c) Breast cancer in females 

(d) Leukemi

9. Ionizing radiation affects which stage of cell cycle ?

 (a) G2 S 

(b) G1 G2 

(c) G2 M 

(d) G0 G1

10. The correct sequence of cell cycle is ?

 (a) G0-G1-S-G2-M

 (b) G0-G1-G2-S-M 

(c) G0-M-G2-S-G1 

(d) G0-G1-S-M-G2 

11. During which phase of the cell cycle the cellular content of DNA is doubled ?

 (a) Mitotic phase

 (b) G1 phase 

(c) G2 phase 

(d) S phase 

12. The tumor suppressor gene p 53 induces cell cycle arrest at ?

(a) G2-M phase

 (b) S-G2 phase

 (c) G1-S phase

 (d) G0 phase

13. Transition from G2 to M phase of the cell cycle is controlled by ?

 (a) Retinoblastoma gene product 

(b) p53 protein

 (c) Cyclin E 

(d) Cyclin B

 14. Fixed time is required for which steps of cell cycle ?

 (a) S 

(b) M

 (c) G1 

(d) G2 

(e) Go 

15. Regarding oncogenesis ?

 (a) Topoisomerase II causes breaks in strands 

(b) p53 is the most common oncogene mutation causing malignancy in humans 

(c) At G2-M phase there is loss of inhibitors controlling cell-cycle 

(d) Decrease in telomerase activity causes anti-tumor effects 

16. Regarding oncogenesis ?

(a) Proto-oncogenes are activated by chromosomal translocation 

(b) Malignant transformations involves accumulation of mutations in proto-oncogenes and tumor suppressor genes 

(c) Point mutation of somatic cells 

(d) Increase in telomerase activity causes anti-tumor effects 

(e) At G2-M phase there is loss of inhibitors controlling cell cycle 

17. The tumor suppressor gene P53 induces cell arrest at ?

 (a) G2 - M phase 

 (b) S- G2 phase 

(c) G1 - S phase

 (d) G0 - phase 

18. Not a premalignant condition ?

(a) Fragile X syndrome

 (b) Down’s syndrome 

(c) Blount’s syndrome

 (d) Fanconi’s syndrome 

19. Which is associated with G2M transition in cell cycle ?

(a) Cyclin A 

(b) Cyclin B 

(c) Cyclin E 

(d) Cyclin D

20. E cadherin gene deficiency is seen in ?

 (a) Gastric cancer

 (b) Intestinal cancer 

(c) Thyroid cancer 

(d) Pancreatic cancer


                                                     ANSWERS


1) b   2) a   3) b   4) d   5) a   6) c   7) d   8) a   9) c   10) a   11) d   12) c   13) d   14) a b d    15) a   16) a    17) c   18) a    19) b   20) a