GENETICS (PART- 3)

                                   




QUESTION


1. Patau syndrome is due to which of the following? 

(a) Trisomy 21 

(b) Trisomy 18 

(c) Trisomy 21

 (d) Trisomy 13

 2. Osteogenesis imperfecta defect in ?

(a) Collagen type I 

(b) Elastin 

(c) Collagen type IV 

(d) Fibrillin 2 

3. In marfan syndrome, the defect is in ?

 (a) Fibrillin I 

(b) Fibrillin II 

(c) Collagen

 (d) Elastin 

4. Karyotyping is done in which phase of cell cycle?

 (a) Anaphase 

(b) Metaphase 

(c) Telophase 

(d) S phase 

5. The number of chromosomes in Turner syndrome is ?

 (a) 47

 (b) 46 

(c) 45 

(d) 44 

6. The number of chromosomes in Klinefelter syndrome is ?

 (a) 47 

(b) 46 

(c) 45

 (d) 44

 7. Chromosomes are visualized through light microscope with resolution of ?

(a) 5 Kb 

(b) 50 mb

 (c) 5 

(d) 500 Kb

 8. Which of the following techniques can be used to detect exact localisation of a genetic locus? 

(a) Chromosome painting 

(b) FISH 

(c) Comparative genomic hybridization 

(d) Western blot

9. If a chromosome divides in an axis perpendicular to usual axis of division it is

 going to form ?

(a) Ring chromosome 

(b) Isochromosome

 (c) Acrocentric chromosome 

(d) Subtelocentric chromosome

10. BRCA 1 gene is located on? 

(a) Chromosome 13

 (b) Chromosome 11 

(c) Chromosome 17 

(d) Chromosome 22 

11. Males are more commonly affected than females in which of the following genetic disorders?

 (a) Autosomal Recessive Disorder 

(b) Autosomal Dominant Disorder 

(c) X-linked Recessive Disorder 

(d) X-linked Dominant Disorder


12. In-situ DNA nick end labeling can quantitate ?

(a) Fraction of cells in apoptotic pathways 

(b) Fraction of cells in S phase

 (c) p53 gene product 

(d) bcr/abl gene

 13. The chances of having an unaffected baby, when both parents have achondroplasia, are ?

 (a) 0% 

(b) 25% 

(c) 50% 

(d) 100% 

14. Father has a blood group B; Mother has AB; Children are not likely to have the following 

blood group ?

 (a) O 

 (b) A

 (c) B

 (d) AB

15. Gene therapy is used for ?

 (a) Cystic fibrosis 

(b) Sickle cell anemia 

(c) Thalassemia 

(d) All of the above


                                                    ANSWERS


1) d   2) a   3) a   4) b   5) c   6) a   7) c   8) b   9) b   10) c   11) c   12) a    13) b   14) a   15) d